Five years prior, a team of scientists figured out how to make humans invisible, but something went wrong, and only two people ever survived. Turner later demands answers from Dalton and the scientist spills the beans. Bishop and Reisner, knowing their careers would end if Maggie talks, declare them fugitives. Frank helps Maggie escape from the police station and they flee in a stolen car. Maggie is taken into protective custody by the police, where Turner's superior and acquaintance, Captain Thomas Harrison, has received orders to have her transferred to the military. He almost catches up to them, but after he is struck and badly injured by a car, he subsequently flees. Several flashbang grenades go off around the house, incapacitating the soldiers and allowing the invisible man to escape in pursuit of Turner and Maggie. Outside, Turner confronts Bishop, realizing that they used him and Lisa to lure the invisible man to the house. Suddenly, armed military commandos appear and storm the house, using thermal goggles to target and corner the invisible man.
Just as he reaches the study where Maggie is, Lisa tracks him down, and he throttles her with a lamp's power cord. When Lisa opens the door to let the cat in, the invisible man sneaks past her into the house. The two detectives stand guard outside Maggie's house. William Reisner, employs Detective Franklin Turner and his partner, Lisa Martinez, to keep Maggie safe, but withholds any information regarding his work. Afraid of further attacks on the remaining scientific personnel, the lab owner, Dr. The police arrive, attempting to conduct a murder investigation - however, the laboratory's military supervisor, an officer called Colonel Gavin Bishop, protests it is an internal military affair and ban the cops from interfering. Suddenly, the man, who faked his absence after all, smashes the device and slashes Dylan's neck. Seemingly accepting this, the man leaves, or rather pretends to leave, and Dylan attempts to call somebody, presumably the law enforcement on his handphone. Dylan eventually surrenders the name of a second scientist, Margaret Dalton, who has the information which the man is seeking. An invisible force brutally beats a scientist, Dylan, to a bloody pulp, dragging him into a washroom, and viciously tortures him for information.
The story begins at a cocktail party is held at the Reisner Institute, a Washington think tank. It stars Christian Slater, Peter Facinelli and Laura Regan. Hollow Man 2 is a science-fiction/horror movie and the sequel to Paul Verhoeven's 2000 film.